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INFLUENCE OF UNSATURATION ON FIBRINOLYTIC ACTIVITY OF FATTY ACIDS
FORT DETRICK FREDERICK MD
Pagination or Media Count:
Long-chain saturated fatty acids are known to accelerate blood clotting and artificial thrombus formation in vitro, and to produce massive thrombosis and death in dogs and mice. We have found that some long-chain fatty acids induce fibrinolytic activity on bovine fibrin films, with some indication that unsaturated acids were most active. Twofold dilutions of the potassium salts of fatty acids were tested in 0.02-ml amounts for ability to lyse unheated bovine fibrin films. An attempt was made to establish the influence of unsaturation and chain length on fibrinolytic activity. The presence of one unsaturated bond appears to make little difference in activity of C16 fatty acids. In C18 and C20 acids, it increases activity roughly tenfold. In C22 and C24 acids it increases activity more than 100-fold. A possible role of fatty acids in regulation of fibrin formation and digestion is suggested.
APPROVED FOR PUBLIC RELEASE