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ANTHRAX INFECTION IN MICE AS A MODEL FOR STUDYING THE DYNAMICS OF THERAPY IN BACTERIAL DISEASES,
FORT DETRICK FREDERICK MD
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The effects of penicillin, dihydrostreptomycin, chlortetracycline, oxytetracycline chloramphenicol, and antiserum on the course of anthrax infection were studied in mice. A model utilizing the quantitative measurements of mean time to death, percentage of survivors, and organism counts in the whole body was employed. By all parameters tested, penicillin and dihydrostreptomycin were the antibiotics of choice in the treatment of the disease. Therapy initiated in the later stages of the disease was more effective than that initiated in the earlier stages. Quantitative studies indicated that it was more difficult to eliminate organisms from the kidney than from any other organ or tissue. This model of the dynamics of antibiotic and antiserum therapy is suggested for the study of other bacterial diseases. Author
APPROVED FOR PUBLIC RELEASE