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RETICULAR CHANGES IN THE RABBIT APPENDIX FOLLOWING THYMIC TRANSPLANTS
FORT DETRICK FREDERICK MD
Pagination or Media Count:
The most striking morphologic similarity between the lymphoid structure of the appendix and the thymus in adult New Zealand rabbits is the constant occurrence of large reticular cell derivatives in the cortico-medullary junction. This can be appreciated in both H and E and PAS preparations. The normal rabbit appendix is an ovoid lymphoid structure covered luminally with one or more layers of modified intestinal epithelium that lacks PAS reactivity but contains foci of lymphocytes. Laterally, the lymphoid structure is separated by thin connective tissue septa carrying blood vessels and lymphatics. When fresh, homologous thymic tissue 1 by 1cm was transplanted beneath the kidney capsule, the lymphoid structure showed progressive changes with the time between 4 hours and 7 days. The intensity of the reaction was graded, and t tests were significant at 0.001. All changes reverted to near normal by 7 days. The PAS reactivity diminished in intensity but not in area with time. No changes occurred in recipient thymus.
APPROVED FOR PUBLIC RELEASE