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INFLUENCE OF MICROORGANISMS, ANTIBIOTICS, AND VITAMIN B12 ON ACUTE CHOLINE DEFICIENCY.
Part 3 of final rept. 1 Jun 65-31 May 66,
ALBERT EINSTEIN COLL OF MEDICINE BRONX NY
Pagination or Media Count:
Since there have been a number of reports on the liver and renal pathology resulting from acute choline deficiency in young animals, a study was made of the possible role of intestinal microorganisms on these factors. Our experiments indicate that the germfree state diminishes and often prevents the renal manifestation of choline deficiency. Its influence on the early accumulation of liver fat is variable, lessening it on a low cholesterol low cystine diet, but enhancing the early liver fat accumulation when cholesterol is present in a high concentration of 5 and cystine in a concentration of 0.4 in the diet. Vitamin B12 was effective in diminishing the severe renal manifestations of acute choline deficiency in open animal room or conventionalized rats but had no added effect on the lessened lesions of the germfree rats. The early liver fat accumulation was not affected by vitamin B12 in any of the groups of rats. Similarly, neither neomycin nor aureomycin diminished the early accumulation of liver fat but there was an indication in 3 separate experiments that aureomycin but not neomycin diminished the severity of the acute nephropathy in open animal room rats.
APPROVED FOR PUBLIC RELEASE