A CLINICOPATHOLOGIC STUDY OF THE EFFECTS OF RIOT CONTROL AGENTS ON MONKEYS. IV. O-CHLOROBENZYLIDENE MALONONITRILE (CS) GRENADE.
Technical rept. Nov 65-Jun 66,
EDGEWOOD ARSENAL ABERDEEN PROVING GROUND MD
Pagination or Media Count:
This is a study of the order, severity, and resolution of pathologic changes in Macaca mulatta monkeys exposed to CS, a riot control agent. When monkeys were exposed to CS Cts of 2700, 8500, 28,500, or 80,000 mg mincu m, the following observations were made 1. The most prominent lesions seen after the two lower doses were mild pulmonary congestion, bronchorrhea, emphysema, and atelectasis. These lesions cleared by 72 hr but recurred at 1 wk and 30 days. 2. Oral and nasal discharges and dyspnea appeared early after a Ct of 28,500. They were most severe between 12 and 24 hr and were resolved by 72 hr. Pneumonia, emphysema, and atelectasis were present 1 wk and 30 days after exposure. 3. Significant lesions were seen radiographically only in those monkeys exposed to a Ct of 80,000. These lesions paralleled those seen on necropsy. At this Ct, edema appeared by 12 hr, peaked between 24 and 48 hr, and cleared by 1 wk. Emphysema and bronchiolitis were present 1 wk and 30 days after exposure. Author
- Medicine and Medical Research
- Chemical, Biological and Radiological Warfare