Accession Number:

AD0806659

Title:

ANTHRAX SEPTICEMIA: BLOOD CELLULAR AND PHYSIOLOGICAL CHANGES DUE TO INTOXICATION,

Descriptive Note:

Corporate Author:

FORT DETRICK FREDERICK MD

Personal Author(s):

• Klein, Frederick
• Lincoln, Ralph E.
• Dobbs, James P.
• Mahlandt, Bill G.
• Remmele, Norman S.

Report Date:

1966-12-01

Pagination or Media Count:

16.0

Abstract:

A depression of the cortical electrical activity, observed on electroencephalograms, and subsequent respiratory failure occurred in rhesus monkeys dying of anthrax. The cardiac activity and respiratory did not change during the disease until, as evidenced by respiratory pattern, acute respiratory distress occurred, at which time typical anoxic responses were observed. White blood cells and the hematocrit readings increased late in the course of disease and several hours after a septicemia had been observed. A terminal toxemia was demonstrable. These terminal responses are essentially identical to those that we have reported to occur in rhesus and chimpanzees challenged with lethal amounts of sterile anthrax toxin. Anthrax is now visualized as a clinically new disease with many similarities to diphtheria, tetanus, and other lethal toxigenic diseases. Author

Descriptors:

• *BACILLUS ANTHRACIS)
• (*SEPTICEMIA
• INFECTIOUS DISEASES
• MONKEYS
• RESPIRATION
• TOXINS AND ANTITOXINS
• ELECTROENCEPHALOGRAPHY
• ELECTROCARDIOGRAPHY
• RESPONSE(BIOLOGY)
• LEUKOCYTES
• PATHOLOGY

Subject Categories:

• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE