THE INFLUENCE OF IRRADIATION ON NEISSERIA MENINGITIDIS L-FORM INFECTION IN MICE.
Annual progress rept. 1 Apr 66-30 Mar 67,
MARY IMOGENE BASSETT HOSPITAL COOPERSTOWN NY
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The pathogenicity of a strain of Neisseria meningitidis derived from a reverted L-form is compared with its parent bacterium. Both strains produced lethal infections in mice but 20 micrograms of penicillin failed to uniformly protect mice against death due to the reverted strain as it did with the parent strain. Total body irradiation increased the fatality rates and prolonged the bacteremias following infection with both strains. Autopsy cultures failed to yield either organism after recovery from bacteremia. Irradiation of mice after recovery from infection with both strains failed to induce recurrent bacteremia. Stabilization of the L-form occurred during these studies, and stable L-forms were found to persist in the tissue of normal mice for at least 5 days. Author
- Medicine and Medical Research