Accession Number:

AD0806604

Title:

THE INFLUENCE OF IRRADIATION ON NEISSERIA MENINGITIDIS L-FORM INFECTION IN MICE.

Descriptive Note:

Annual progress rept. 1 Apr 66-30 Mar 67,

Corporate Author:

MARY IMOGENE BASSETT HOSPITAL COOPERSTOWN NY

Personal Author(s):

• Page, Malcolm I.

Report Date:

1967-01-30

Pagination or Media Count:

7.0

Abstract:

The pathogenicity of a strain of Neisseria meningitidis derived from a reverted L-form is compared with its parent bacterium. Both strains produced lethal infections in mice but 20 micrograms of penicillin failed to uniformly protect mice against death due to the reverted strain as it did with the parent strain. Total body irradiation increased the fatality rates and prolonged the bacteremias following infection with both strains. Autopsy cultures failed to yield either organism after recovery from bacteremia. Irradiation of mice after recovery from infection with both strains failed to induce recurrent bacteremia. Stabilization of the L-form occurred during these studies, and stable L-forms were found to persist in the tissue of normal mice for at least 5 days. Author

Descriptors:

• *NEISSERIA MENINGITIDIS
• RADIATION EFFECTS
• INFECTIOUS DISEASES
• MICE
• PATHOLOGY
• BLOOD
• SURVIVAL(PERSONNEL)
• GROWTH(PHYSIOLOGY)

Subject Categories:

• Medicine and Medical Research
• Radiobiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE