Accession Number:

AD0806433

Title:

EXPERIMENTAL HYPOTHERMIA AND RESUSCITATION,

Descriptive Note:

Corporate Author:

ARMY MEDICAL RESEARCH LAB FORT KNOX KY

Report Date:

1958-07-09

Pagination or Media Count:

21.0

Abstract:

An attempt was made to determine if continuous intravenous norepinephrine infusion alters lethality of blood stream-cooling in dogs and also its effect when administered during rewarming. To compare cardiovascular responses to hypothermia induced by ambient air- and blood stream-cooling. To explore intra-auricular pacemaking and external artificial stimuli defibrillation as means of resuscitation in the hypothermic dog with intact chest. To compare open chest with closed chest resuscitation efforts. To study various other parameters of interest. Intravenous norepinephrine infusions broaden markedly the hypothermic range in blood stream-cooled dogs. There is also evicence that norepinephrine is beneficial during rewarming procedures. Induction of hypothermia in the anesthetized dog by blood stream-cooling is more hazardous than air-cooling as judged by average temperatures to which the body can be lowered before the onset of ventricular fibrillation or cardiac standstill. Closed chest defibrillation, with 500 volts discharged across the chest wall, was successful six out of twenty times in reverting hypothermic ventricular fibrillation to sinus rhythm with ultimate survival of the animals. Intra-auricular pacemaking gives promise of clinical applicability in the defibrillated or arrested heart. Author

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE