THE EXCRETION AND DISTRIBUTION OF LITHIUM IN THE DOG.
ARMY MEDICAL RESEARCH LAB FORT KNOX KY
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The experiments here reported were carried out to investigate the renal excretion of lithium administered to experimental animals. The distribution of the salt in the body, its excretion by extrarenal routes, and some observations on its toxicity were included, the whole study being planned to obtain information bearing on the use of lithium salts by man. Injected lithium as chloride is rapidly excreted, approximately at the same rate as potassium. Small quantities are excreted by way of the gastrointestinal tract. It appears to be uniformly distributed in the body water when equilibrium is reached. It is excreted by the kidneys by glomerular filtration followed by tubular reabsorption of 57 to 99 percent of the filtered quantity, at serum lithium levels up to 17 mEqL. The renal tubules show little evidence that they can distinguish between lithium and potassium. In these experiments no interference by lithium with the excretion of sodium was noted.
- Anatomy and Physiology