BLOOD AMINO ACID LEVEL AND ADRENAL CHOLESTEROL CONTENT DURING TOURNIQUET SHOCK IN THE RAT WITH AND WITHOUT SALINE ADMINISTRATION,
ARMY MEDICAL RESEARCH LAB FORT KNOX KY
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In the course of studies designed to investigate the sparing effect of saline administration in lowering mortality of rats in tourniquet shock it became of interest to know the influence of this therapy on the blood amino acid level and the adrenal cholesterol content. A shock-like state was produced in rats by applying rubber band tourniquets to the limbs for a certain length of time and then releasing them. A progressive increase in blood amino acid and urea nitrogen occurred after the release of the tourniquets. Application of the rubber bands per se had no effect on these blood constituents but was found to cause a definite stimulation of the adrenal cortex as indicated by a lowering of the adrenal cholesterol content. Release of the tourniquets produced a further decline in the adrenal cholesterol content. The sparing effect of 0.9 percent NaCl administration to rats during tourniquet shock was found to be associated with a decrease in the elevation of blood amino acid concentration and in the fall in the adrenal cholesterol content when compared with untreated animals.
- Anatomy and Physiology