Accession Number:

AD0806406

Title:

THE RENAL EXCRETION OF SODIUM AND POTASSIUM IN THE DOG,

Descriptive Note:

Corporate Author:

ARMY MEDICAL RESEARCH LAB FORT KNOX KY

Report Date:

1949-02-25

Pagination or Media Count:

22.0

Abstract:

Studies were carried out on unanesthetized dogs to determine some of the factors controlling the fraction of filtered sodium and potassium reabsorbed by the renal tubules. The interference with the reabsorption of each of these ions by the other and the phenomenon of tubular secretion of potassium were investigated. Filtration rate as measured by inulin and creatinine clearance and effective renal plasma flow as measured by sodium para-aminohippurate clearance were determinded before and during the intravenous infusion of 0.9 NaCl, 10 NaCl and 1.2 KCl solutions. The percentage of filtered electrolyte reabsorbed for both sodium and potassium was measured, and the serum concentration of each ion was allowed to vary over wide ranges while that of the other ion remained at normal levels. 1.2 KCl solution was also infused into dogs previously fed KCl for a week. The percentage of filtered sodium which is reabsorbed by the tubules is functionally related to the serum sodium concentration. The percentage of filtered potassium which is reabsorbed by the tubules is related to the rate of filtration of potassium. The presence of the chloride salt of each ion in the glomerular filtrate depresses the reabsorption of the other ion. The ingestion of potassium chloride prior to the infusion of this salt augments the depression of potassium reabsorption which normally follows an increased filtration of potassium. Author

Subject Categories:

  • Biochemistry
  • Anatomy and Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE