Accession Number:

AD0801537

Title:

METABOLISM AND PHARMACOLOGY OF FLUORINE-CONTAINING COMPOUNDS

Descriptive Note:

Final rept. 3 Feb 1965-1 Jun 1966

Corporate Author:

MIDWEST RESEARCH INST KANSAS CITY MO

Personal Author(s):

Report Date:

1966-07-01

Pagination or Media Count:

85.0

Abstract:

Acute inhalation, intraperitoneal andor oral toxicities of AMOX and TAMA were determined in rats and mice. IP absorption was studied in rats. AMOX produced strong irritation resulting in pulmonary edema and hemorrhage after inhalation and local denatured changes and accumulation of clear exudate after intraperitoneal injection. TAMA was less toxic on the weight basis. Both AMOX and TAMA were quickly absorbed after IP injection. Fluoride increased quickly in the blood and concentrated in various tissues especially in the thyroid, bone and teeth. Most of the administered fluoride was excreted in the urine and a considerable amount was also recovered in the feces.

Subject Categories:

  • Anatomy and Physiology
  • Inorganic Chemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE