Soft Tissue Response to a Series of Dense Materials and Two Clinically Used Biomaterials.
Technical rept. no. 4, 1 May 73-30 Jun 74,
CLEMSON UNIV S C COLL OF ENGINEERING
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Disc-shaped implants of spinel, alumina, mullite, zircon, a cast Co-Cr-Mo alloy, and ultra-high molecular weight polyethylene UHMWPE, were implanted in the paraspinalis muscle of twelve adult, male, White New Zealand rabbits. Prior to implantation the implants were characterized with respect to size and shape, weight, and surface roughness. After periods of one month, two months, and four months the rabbits were sacrificed and the tissue specimens were retrieved with the implants still intact. No surface degradation of any of the materials was detected using scanning electron microscopy. Fibrous tissue seems to adhere to the UHMWPE implants more than any other material used in this study. Large amounts of fibrous tissue were also found to adhere to the cast Co-Cr-Mo alloy implants. The histological results indicated that within the limits of this investigation, the biocompatibility of the ceramic materials used in this study compares favorably with the clinically used cast Co-Cr-Mo alloy implants and the UHMWPE implants. Modified author abstract
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