Accession Number:

AD0787464

Title:

Polydimethylsiloxane: A Feasibility Study of a Thromboresistant Biomaterial,

Descriptive Note:

Corporate Author:

ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD

Report Date:

1974-06-01

Pagination or Media Count:

19.0

Abstract:

Silicone rubber as used in blood contacting situations usually contains fillers, catalyst and other additives. In this study, polydimethylsiloxane PDMS alone was cross-linked by ionizing radiation in a nitrogen atmosphere to produce a pure silicone rubber. This material exhibited a Lee-White clotting time over 45 minutes and a clotting time of 90 minutes when air-blood contact was minimized. Comparable times for commercial silicones are 25 and 60 minutes. In extracorporeal testing using a Mini Lung, an irradiated PDMS coated membrane demonstrated greatly improved thromboresistance over standard silicone rubber membranes. Author

Subject Categories:

  • Medical Facilities, Equipment and Supplies

Distribution Statement:

APPROVED FOR PUBLIC RELEASE