Biochemical Aspects of Morphine Tolerance and Physical Dependence.
Annual rept. no. 3, Oct 73-30 Sep 74,
MICHIGAN STATE UNIV EAST LANSING DEPT OF PHARMACOLOGY
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The specific binding of narcotic agonist and antagonist to brain tissue can be studied in vitro using tritium-labeled compounds. Conditions necessary to study the specific binding which are relevant to the drug-receptor interactions are specified. Remarkable similarities exist between the specific binding observed in vitro and opiate binding to their receptor observed in vivo. Changes in macromolecules involved in the specific binding are currently under investigation. The data indicated that there are no remarkable differences in development of physical dependence on morphine due to the difference in age of subjects. The development of tolerance, however, was clearly influenced by the age of the subject younger animals developed tolerance more rapidly than older animals when both groups of animals were injected repeatedly with equal doses mgkg or equipotent doses of morphine. Modified author abstract