Accession Number:

AD0787065

Title:

Hemostatic Alterations Following Severe Dysbaric Stress

Descriptive Note:

Medical research progress rept. no. 3

Corporate Author:

NAVAL SUBMARINE MEDICAL RESEARCH LAB GROTON CT

Report Date:

1974-02-12

Pagination or Media Count:

16.0

Abstract:

Hemostatic parameters were measured in the blood of mature Sprague Dawley rats during a three-day period following exposure to a compression- decompression schedule designed to produce severe dysbaric stress. The animals were compressed on air to 300 feet of sea water for 30 minutes and stage decompressed over a 42-minute interval. Acute decompression stress produced a transient decrease in clotting time. Circulating platelet population was unchanged during the early phase of recovery from severe decompression but significantly declined by two days post-surfacing and then returned to control levels by the end of the observation period. Associated with this thrombocytopenic episode was a tendency toward platelet aggregation. Core temperature measurements indicated the presence of a chronic hyperthermic condition. A significant hyperfibrinogenemia developed by one day post-dive with a normalization of fibrinogen content occurring during the following two days. No alterations in either prothrombin time or partial thromboplastic time were detected. This animal research has much significance in the biomedical aspects of human diver safety and health.

Subject Categories:

  • Stress Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE