Toxicologic and Physiologic Effects of Bromotrifluoromethane in Hyperbaric Atmospheres.
Medical research progress rept. no. 2,
NAVAL MEDICAL RESEARCH INST BETHESDA MD
Pagination or Media Count:
Electrocardiograms, evoked visual potentials and blood gases were recorded in cats breathing bromotrifluoromethane at 165 ft. of seawater 73 psig. The cats breathed the bromotrifluoromethane 228 mm Hg in air for five min. Heart rates were not significantly altered, but the QRS intervals were increased from a control value of 0.05 to 0.06 sec. The increase in QRS interval was associated with frequent nodal beats. Respiratory rate and the Paco2 increased. Small reductions in the amplitude and increased latency of the lateral geniculate response were recorded. In cats sacrificed immediately after exposure, electron microscopic examination of the lungs demonstrated minimal engorgement of alveolar capillaries and small numbers of acute inflammatory cells. The alveolar basement membrane was thickened with vacuolation of alveolar capillary endothelium and alveolar epithelium. No morphologic changes were seen in cats sacrificed five days after exposure. Author
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