Accession Number:

AD0786973

Title:

Histamine Formation and Histamine Liberation in Traumatic Shock and Shock Resistance,

Descriptive Note:

Corporate Author:

FOREIGN TECHNOLOGY DIV WRIGHT-PATTERSON AFB OHIO

Personal Author(s):

Report Date:

1974-09-19

Pagination or Media Count:

17.0

Abstract:

It was found that the liberation of vasoactive substances capable of increasing capillary permeability increases significantly in traumatic shock Noble-Collip drum test, directly upon the effect of the traumatic stress. Between 1 and 6 hours following the effect, histamine formation increases considerably, not only locally but over the entire organism. This is the result of increased 1-histidine decarboxylase activity. In animals adapted to trauma, in the state of specific and nonspecific resistance, the increased liberation of vasoactive substances and the increased formation of histamine does not occur after the traumatic shock. The same thing applies after the prior injection of serum from trauma-adapted animals. The authors found that a humoral factor, the earlier reported adaptation factor, resistine is responsible for the inhibition of histamine liberation and formation.

Subject Categories:

  • Anatomy and Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE