The Effect of Prior in situ Cooling on the Viability of the Excised Heart.
Final technical rept.,
GEORGETOWN UNIV WASHINGTON D C DEPT OF BIOLOGY
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Methods for the preservation of isolated organs have rarely considered the capacities for physiological adaptation possessed by living material. The primary purpose of this study was to determine if there is improved viability of an isolated perfused heart if the donor has been exposed previously to cold stress either in the form of long term environmental exposure or short term hypothermia. Following special treatments of donor rabbits, isolated hearts were maintained under pulsatile perfusion using the Lindbergh-Carrel perfusion system. In these experiments cold acclimation and prior hypothermia did not contribute significantly to the viability of the isolated hearts. Other evidences, based on whole animal studies, continue to suggest that prior exposure of the whole animal conditions allowing acclimation to stress might also provide individual organ acclimation and therefore assist organ preservation attempts. The authors isolated organ studies did not support this supposition. Modified author abstract
- Anatomy and Physiology