Effects of Hypoxic Stress on Survival Times of Mice Infected with Either 'Staphylococcus aureus' or 'Klebsiella pneumoniae'
NAVAL MEDICAL RESEARCH UNIT NO 2 MANILA(PHILIPPINES)
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Comparative studies of the effect of hypoxic stress on infection with gram positive or gram negative bacteria were conducted. Survival times of mice infected with either S. aureus or K. pneumoniae were significantly extended by treatment with 10 oxygen begun immediately post infection. Delayed treatment was ineffective. Hypoxia induced by 0.6 atm. was detrimental in treatment of infected mice. This latter treatment had no effect on bacterial counts in organs of infected mice. Treatment with 10 oxygen did, however, increase numbers of S. aureus in lungs and livers of infected mice. No effect of this treatment on bacterial counts was seen in mice challenged with K. pneumoniae. Mice with diffuse type haemoglobin were found to be more resistant to both infections than animals with the single type haemoglobin. Thus, under some circumstances, hypoxia can prolong survival times of mice infected with S. aureus or K. pneumoniae, apparently through effects on host metabolism.
- Medicine and Medical Research