Meningococcal Antigens: An Immunochemical Approach to the Development of a Meningitis Vaccine,
WALTER REED ARMY INST OF RESEARCH WASHINGTON D C
Pagination or Media Count:
The authors isolated the protein and lipopolysaccharide LPS components of the meningococcal outer membrane and shown that they are both shared across serogroup lines. Results of specific hemagglutination HA assays indicated that persons who acquire systemic meningococcal disease usually develop a substantial increase in antibody titer against both the LPS and the protein antigens. Asymptomatic nasopharyngeal carriers of group B meningococci, however, appeared to respond principally to the protein antigens. The outer membrane protein has been considered to be the best candidate for testing as a potential vaccine against group B meningococci. In preliminary tests in laboratory animals the two trial vaccine lots were found to be nontoxic in mice and guinea pigs, nonpyrogenic in rabbits, protective in mice and capable of inducing bactericidal antibody in rabbits.