Metabolic Rate, Ambient Temperature and Catecholamines: Interrelationships Following Thermal Injury,
BROOKE ARMY MEDICAL CENTER FORT SAM HOUSTON TEX ARMY INST OF SURGICAL RESEARCH
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Hypermetabolism characterizes the metabolic response to thermal injury, and the magnitude of this post-traumatic physiologic alteration is closely related to the extent of injury. Negative nitrogen balance, loss of other intracellular constituents, and a rapid decrease in body weight are consequences of the increase in metabolic activity, and extensive loss of protoplasmic mass may result in severe erosion of energy and protein stores essential to optimal body function. Similarities between the thermally injured and individuals with thyrotoxicosis prompted early metabolic and endocrine studies, but the increased oxygen consumption has not been related to abnormal thyroid function. The purpose of this study was to define the relationship between surface cooling and hypermetabolism and to determine the mediator of the profound hypercatabolic response following thermal injury.
- Stress Physiology