Cellular Localization of Calcium-Binding Protein,
LETTERMAN ARMY INST OF RESEARCH SAN FRANCISCO CALIF
Pagination or Media Count:
The authors have provided histochemical evidence that calcium binding protein CaBP is localized in the paracellular and basal region of intestinal cells, thus strengthening the hypothesis that the primary calcium transporting mechanism is localized in this region. The unique previously unreported distributuion of CaBP in renal tubular epithelium will require considerable rearrangement of current concepts of renal calcium metabolism. In fact, the apparent sepcialization of renal tubules may have implications of significance to renal physiology in general, since this degree of renal tubule heterogenicity has not been previously reported. Also, the demonstration of CaBP specific staining in pancreatic islet cells is a completely new finding, the significance and implications of which will only be known through future research.