Bolivian Hemorrhagic Fever in Rhesus Monkeys: Treatment with Specific, Homologous Antibody
ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD
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Data from Machupo virus infected rhesus monkeys showed that species to be a useful model for Bolivian hemorrhagic fever BHF in humans. The clinical signs, hematologic data and histopathologic lesions were generally similar to those seen in humans except that the disease course was more severe and perhaps somewhat briefer in the monkey. Data showed that relatively low prophylactic doses of specific antibody given at about the time of exposure to BHF prevented the development of clinical signs of disease BHF, unlike most viral diseases, can be successfully treated, in monkeys at least, if antibody therapy is initiated early after the onset of clinical signs and the maintenance of detectable levels of passive antibody with daily injections may permit successful treatment as much as four days after the clinical signs have become apparent.
- Medicine and Medical Research