The Role of the Plasma Kallikrein-Kinin-Kininase System in Shock.
Final technical rept.,
TEXAS UNIV HEALTH SCIENCE CENTER DALLAS
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Investigation of the various components of the plasma kallikrein-kinin system in the plasma of patients suffering from septic shock due to combat trauma suggested that hypotensive peptides were explosively liberated in the blood. The most interesting finding was the statistically significant correlation between kininogen level and survival rate in these patients. The kinin precursor level kininogen decreased to near zero in blood of the patients who died, while the level of this protein rose to normal in those who survived. Two enzymes were purified that might be important in shock. The first is the angiotensin I converting enzyme or kininase II of lung, kidney, and blood. The second enzyme is a lysosomal prolylcarboxypeptidase found in leucocytes and in kidney.