A Comparative Study of the Effectiveness of the Inhalation and the Subcutaneous Methods of Administration of Kanamycin in the Treatment and Prophylaxis of Induced Pneumonia in Albino Mice
ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD FORT DETRICK
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Inhalation of kanamycin aerosol has an active local effect on the infection process associated with induced pneumonia in white mice it prevents the development of sepsis. The use of this aerosol is particularly effective in early treatment. Use of kanamycin aerosol is less effective in the later stages of pneumonia, this being associated with advance of the septic process and with reduction in the inhalation dose, which results in lowered pulmonary ventilation. Prophylaxis with kanamycin aerosol is highly effective when applied 1-3 hours before infection less so when applied 24 hours before infection. A single subcutaneous administration of kanamycin somewhat retards development of the process of sepsis, as shown by the infected and the control groups, but has little effect on survival rate.