Accession Number:

AD0784927

Title:

The Antiviral Effect of Some Derivatives of Tilorone HCl on TBE in White Mice

Descriptive Note:

Technical Report

Corporate Author:

ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD FORT DETRICK

Personal Author(s):

Report Date:

1974-09-18

Pagination or Media Count:

13.0

Abstract:

Four derivatives of tilorone HCl were tested against tickborne encephalitis TBE in mice and compared with tilorone HCl. All substances induced interferon and thus protected mice against infection. The drugs were active not only after oral but also after subcutaneous and intraperitoneal application. Rather an antagonistic effect was observed when the compounds were used combined. However treatment of mice with tilorone HCl or a derivative in combination with Poly IC enhanced survival of mice.

Subject Categories:

  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE