The Antiviral Effect of Some Derivatives of Tilorone HCl on TBE in White Mice
ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD FORT DETRICK
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Four derivatives of tilorone HCl were tested against tickborne encephalitis TBE in mice and compared with tilorone HCl. All substances induced interferon and thus protected mice against infection. The drugs were active not only after oral but also after subcutaneous and intraperitoneal application. Rather an antagonistic effect was observed when the compounds were used combined. However treatment of mice with tilorone HCl or a derivative in combination with Poly IC enhanced survival of mice.