Studies of Regeneration of Mammalian Skeletal Muscle.
Final technical rept. Apr 73-Jun 74,
BRISTOL UNIV (ENGLAND) DEPT OF PHYSIOLOGY
Pagination or Media Count:
Muscles of rat hind limbs were minced into 1mm fragments and transplanted. A transplant of tibialis anterior into its own bed was more likely to regenerate than one into a recipient rat. Spinal transection or prior deveration of the muscle also resulted in a lower incidence of regeneration than simple autotransplantation. The regenerate began to respond to a nerve stimulus at two weeks and tetanic tension increased at a rate of 6.8 gday reaching 560 g at 100 days which is about 10 of the expected tension for normal animals. There was no lessening in the rate of progression at the latest stage examined 75 days so far. Regeneration was slower in adult animals or if the leg was fixed in a plaster cast or if the muscles were denervated 28 days prior to the transplant. Author
- Anatomy and Physiology