The Growth of Plasmodium berghei under Semi in Vivo/in Vitro Conditions.
Final technical rept.,
MEDICAL RESEARCH COUNCIL HARROW (ENGLAND) CLINICAL RESEARCH CENTRE
Pagination or Media Count:
Mouse blood containing parasites of P. berghei was placed in diffusion chambers inserted into the peritoneal cavity of mice. The parasites failed to grow for more than one generation in these chambers. Two hypotheses are suggested to explain this failure to multiply Multiplication of plasmodia requires an active blood circulation, with alternation between capillaries of the lungs and those of the deep tissues. Experiments yielded no evidence to support this suggestion. Multiplication of plasmodia depends on their sequestration in some special organ or tissue. This hypothesis appears very probable but the available evidence fails to identify the site. The question should be further investigated by histological sections, and special attention should be paid to the liver, the ventricles of the heart and to the lungs, with subsidiary attention to the marrow, adipose tissue and placenta. Author