Propagation of Antibody Forming Cells in Diffusion Chambers.
Annual rept. 1 Mar 73-28 Feb 74,
ILLINOIS UNIV URBANA DEPT OF VETERINARY PATHOLOGY AND HYGIENE
Pagination or Media Count:
Mouse spleen cells secondarily stimulated with a small dose of antigen, which elicited few antibody-forming cells, produced antibodies of avidity no greater than that of antibodies synthesized by cells stimulated with an optimal dose of antigen. This result is in conflict with the hypothesis that maturation of the immune response is based on competition for limiting amounts of antigen among cells with receptors of varying avidity. In other work, evidence was obtained that the ability of mice to synthesis anti-DNP antibodies of high avidity is controlled by a single dominant autosomal gene that the helper function of carrier-specific T-cells in the secondary response to a hapten-carrier conjugate may be replaced by anti-carrier serum and that exposure of spleen cells from mice with both B-cell and T-cell tolerance to antigen-antibody complexes terminates the tolerant state. Author
- Anatomy and Physiology