Accession Number:

AD0784727

Title:

Factors Affecting the Muscle Depolarization Due to 'Conus achatinus' Toxin,

Descriptive Note:

Corporate Author:

DEFENCE STANDARDS LABS MARIBYRNONG (AUSTRALIA)

Personal Author(s):

Report Date:

1973-06-25

Pagination or Media Count:

8.0

Abstract:

The action of Conus achatinus toxin on mammalian skeletal muscle has been investigated. Toxin-induced membrane depolarization was wholly or partly antagonized by manganese ions, procaine and a range of sulfhydryl reagents. Toxin-induced twitch blockade was antagonized by dithiothreitol. Possible modes of action of the toxin and the antagonist compounds are discussed. Author

Subject Categories:

  • Toxicology
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE