Accession Number:

AD0784701

Title:

Concerning the Crossed Allergic Reactions Caused by Conjugates of Dinitrophenol with Protein, and Their Specific Inhibition,

Descriptive Note:

Corporate Author:

FOREIGN TECHNOLOGY DIV WRIGHT-PATTERSON AFB OHIO

Report Date:

1974-08-15

Pagination or Media Count:

11.0

Abstract:

The sensitization of guinea pigs by conjugates of dinitrophenolbovine gamma-globulin and dinitrophenolbovine fibrinogen showed the possibility of developing immediate-type crossed allergic reactions anaphylactic shock. Intravenous introduction before testing the conjugates to dinitrochlorbenzene DNCB-sensitized guinea pigs produced a more intensitive cross inhibition of development of skin-allergic contact reaction contact dermatitis than the same intravenous injection of DNCB in TWEEN-80. The depression of dermatitis is expressed visually and histologically the less the period between the hyposensitizing introduction of allergen and testing.

Subject Categories:

  • Anatomy and Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE