Concerning the Crossed Allergic Reactions Caused by Conjugates of Dinitrophenol with Protein, and Their Specific Inhibition,
FOREIGN TECHNOLOGY DIV WRIGHT-PATTERSON AFB OHIO
Pagination or Media Count:
The sensitization of guinea pigs by conjugates of dinitrophenolbovine gamma-globulin and dinitrophenolbovine fibrinogen showed the possibility of developing immediate-type crossed allergic reactions anaphylactic shock. Intravenous introduction before testing the conjugates to dinitrochlorbenzene DNCB-sensitized guinea pigs produced a more intensitive cross inhibition of development of skin-allergic contact reaction contact dermatitis than the same intravenous injection of DNCB in TWEEN-80. The depression of dermatitis is expressed visually and histologically the less the period between the hyposensitizing introduction of allergen and testing.
- Anatomy and Physiology