Toxicological Evaluation of Polyvinyl Acetate (PVA) Emulsion Dust Control Material, May 1973-March 1974.
ARMY ENVIRONMENTAL HYGIENE AGENCY ABERDEEN PROVING GROUND MD
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The relative toxicity of polyvinyl acetate PVA emulsion dust control material was investigated using laboratory animals. PVA emulsion is a mixture composed of a base latex plasticized with cresyl diphenyl phosphate Santicizer 140 and tetraethylene glycol di-2-ethylhexanoate Flexol 4G0. The PVA emulsion, base latex, and Flexol 4G0 produced moderate to severe primary irritation when applied to the intact and abraded skin of rabbits. Santicizer 140 did not produce eye or skin irritation but did cause a reduction in blood plasma cholinesterase activity of squirrel monkeys and coturnix quail 24 hours after a single intraperitoneal injection. Data indicate little acute toxic hazard from ingestion of PVA emulsion or its component compounds. No clinical significant changes occurred in groups of dogs or rats as a result of repeated exposures to aerosols of PVA emulsion. Modified author abstract