Experimental Respiratory Infection with 'Pasteurella multocida' and 'Bordetella bronchiseptica' in Rabbits
Technical Report,01 Feb 1974,31 Mar 1974
EDGEWOOD ARSENAL ABERDEEN PROVING GROUND MD ABERDEEN PROVING GROUND
Pagination or Media Count:
Eight- to ten-weekold offspring of a colony of specific pathogen-free rabbits were exposed to cultures of Pasteurella multocida and Bordetella bronchiseptica. Two groups of nine animals were exposed to either bacterium intranasally and sacrificed 2, 7, 14, and 21 days postinoculation. Five of nine rabbits in each group developed a mucopurulent nasal discharge 4 to 7 days postinoculation. The remaining four rabbits in each group failed to develop clinical signs. The gross and microscopic lesions did not differ significantly in character or distribution among the inoculated rabbits. The infection was characterized by an acute upper respiratory syndrome accompanied by a mild bronchopneumonia.