Derivatives of Carbinol Amines as Potential Antimalarials.
NAVAL ACADEMY ANNAPOLIS MD
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Three basic types of compounds which have exhibited interesting antimalarial activity towards new strains of malaria are pyridine methanols, quinoline methanols, and phenanthrene methanols. In this project, it was proposed that these molecules be modified. Modifications demonstrated include reactions with acid chlorides to form esters, reactions with carbonyl compounds to form oxazolidines and oxazines, and reactions with acids to form salts. Preliminary studies relating to these modifications were also made. Also, a discussion of the problem of malaria, as well as the specific problems encountered in the above syntheses, has been made. Modified author abstract
- Organic Chemistry