Deposition of Ultrafine Aerosols in the Respiratory Tract of Human Volunteers.
Special publication, Aug 72-Jun 73,
EDGEWOOD ARSENAL ABERDEEN PROVING GROUND MD
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Techniques were devised for generating and sizing an ultrafine, monodisperse aerosol and the aerosol was used in deposition studies in the respiratory tract of human test subjects. A simple technique was developed for producing and sizing an 0.08 micrometer aerosol tagged with TC99m, a gamma-emitting radioisotope with a half life of 6 hours. The test aerosol was reasonably monodisperse, exhibiting geometric standard deviations in the range of 1.05 to 1.35. Hygroscopic growth of the test aerosol under conditions simulating humidification in the respiratory tract was measured. An apparatus was constructed for use in conducting aerosol breathing studies. The experimental setup would also be suitable for lung scanning studies, including regional deposition studies. Fractional deposition of the test aerosol was measured for both mouth breathing and nasal breathing. Author
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