The Failure of Buffered 5-Hydroxytryptamine to Increase Brain Capillary Permeability to Albumin
ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD
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The effect of buffered 5-hydroxytryptamine 5-HT on the blood-brain barrier to 125I-albumin was studied in 14 rhesus monkeys. 5-HT was introduced into the lateral ventricle by ventriculocisternal perfusion resulting in a concentration gradient in the periventricular tissue from 1 to 800 times endogenous levels. Buffered 5-HT failed to induce an increase in periventricular vascular permeability to 125I-albumin. Earlier reports to the contrary may have resulted from species differences, as well as failure to control physiologic parameters and the use of highly acidic 5-HT preparations.