Accession Number:

AD0781961

Title:

Reactivation of Phosphorylated Acetylcholinesterase of Human Erythrocytes by Means of TMB-4, Toxogonin, 2-PAM and 2-PAS,

Descriptive Note:

Corporate Author:

ARMY FOREIGN SCIENCE AND TECHNOLOGY CENTER CHARLOTTESVILLE VA

Personal Author(s):

Report Date:

1973-09-21

Pagination or Media Count:

6.0

Abstract:

Human erythrocytes were treated with the toxic pesticide DDVP 0,0 dimethyl -0-2,2-dichlorovinylphosphate. This caused an inhibition of the enzyme, acetylcholinesterase, contained in the erythrocytes of 88.8 on the average. The cells were washed and treated with four widely used acetylcholinesterase reactivators, and the activity of the enzyme was then measured. TMB-4 and Toxogonin proved to be more effective than 2-PAM or 2-PAS as reactivators.

Subject Categories:

  • Biochemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE