The Reversible Effects of Acute Adenine Toxicity in Rats.
ARMY MEDICAL RESEARCH LAB FORT KNOX KY
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From this study in a large population of rats, adenine toxicity to renal tissue was found to be dose-rate related. Average transient weight loss was encountered at all levels however, recovery by the end of 30 days was complete. It was shown that a dose level of 25 mgkg body weitht is the only dose level at which no evidence of morphologic renal damage occurs, although a single transient rise in BUN and creatinine values took place. At higher dose levels, below the LD50, a more prolonged transient uremia and renal impairment was a consistent finding. Acute tubular necrosis was encountered initially however, a complete morphologic recovery was documented by one week in 50 and 100 mgkg body weight dose levels. Based on information obtained from animal models, adenine in doses less than 25 mgkg body weight would be reasonable if renal function was normal. Modified author abstract