In vivo Distribution of Injected 14C-Dioxyadenine in Tissues and Organs of Normal Rates.
ARMY MEDICAL RESEARCH LAB FORT KNOX KY
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Dioxyadenine is rapidly distributed throughout the organs and tissues of the rat and specific concentration occurs in a few organs. High retention of the radioactive material is observed in the kidney which also shows a very high specific activity. Smaller but significant concentrations of the 14C-compound are present in muscle and skin and cannot be attributed to the presence of residual blood. The radioactive material is gradually released from the various tissues and, at 24 hr after injection, 92 of the injected dose is found in urine and bladder. The kidney tissues show crystal deposition and morphological damage. Author