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Peculiarities of Pyridoxine and Nicotinic Acid Metabolism in Experimental Animals under the Physical Stresses of Prolonged Swimming,
ARMY FOREIGN SCIENCE AND TECHNOLOGY CENTER CHARLOTTESVILLE VA
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It has been established in experiments that the maximum physical stress swimming until submergence of white rats causes a significant reduction in elimination of 4-pyridoxinic acid and N1-methylnicotinamide with the daily urine, as well as a decrease in nicotinamide nucleotide coenzyme NAD NADP content in the liver. Additional administration of increased quantities of pyridoxine and nicotinic acid in the ration increased the excretion of the metabolites studied and maintained the nicotinic acid coenzyme content in the liver at a high level. In animals, not receiving pyridoxine or nicotinic acid with the ration, a decrease in body weight and a reduction in the mean swimming time were observed. The results obtained provide a basis for proposing an increased requirement of the bodies of white rats for pyridoxine and nicotinic acid during the physical stresses of prolonged swimming.
APPROVED FOR PUBLIC RELEASE