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Sequential Immunization of Spider Monkeys with Three Group B. Arboviruses: Yellow Fever, Langat, and Dengue-2.
Annual progress rept.,
YALE UNIV NEW HAVEN CONN SCHOOL OF MEDICINE
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Four spider monkeys were sequentially vaccinated at 30-days intervals with yellow fever 17D, a Langat and a dengue type 2 attenuated strains. Four months after the last vaccination these monkeys and 4 controls which had been injected the vaccine substrates only were subcutaneously challenged with Japanese encephalitis virus. As anticipated, none of these animals developed signs of illness viremia titrations done daily for seven consecutive days after challenge were used as a criterion for protection. No protection was detected as a result of vaccination. Author
APPROVED FOR PUBLIC RELEASE