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Some Effects of DBcAMP on Rabbit Bone Marrow Cells in Culture: Cell Clumping and Cholinesterase Production.
Technical rept. Jul 72-Jul 73,
EDGEWOOD ARSENAL ABERDEEN PROVING GROUND MD
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Bone marrow cells derived from phenylhydrazine-treated rabbits were grown in vitro for 24 hours. Marrow cultivated in the presence of .001 M dibutyryl 3,5-cyclic monophosphate DBcAMP formed large, dense cell clusters whereas those from control cultures formed smaller, more discrete cell clusters. Actinomycin D inhibited cluster formation. Erythroid cell maturation was also inhibited in the presence of DBcAMP. However, cholinesterase synthesis was enhanced. Most of the cells containing newly synthesized membrane-bound cholinesterase are erythroid. On the basis of the data obtained, it is suggested that the cyclic nucleotide may stimulate membrane protein synthesis. Author
APPROVED FOR PUBLIC RELEASE