Accession Number:

AD0779803

Title:

Functional Significance of Localization of Changes in Catecholamine Metabolism in the Central Nervous System during Postdiphtherial Polyneuritis and Experimental Allergic Encephalomyelitis,

Descriptive Note:

Corporate Author:

FOREIGN TECHNOLOGY DIV WRIGHT-PATTERSON AFB OHIO

Personal Author(s):

Report Date:

1974-04-30

Pagination or Media Count:

11.0

Abstract:

The development of postdiphterial polyneuritis PDN and experimental allergic encephalomyelitis EAE is preceded in the preparalytic period by accumulation of catecholamines in the hypothalamus and also in those sections of the nervous system in which allergic inflammation subsequently arises the spinal cord, the sciatic nerves. The change in the content of catecholamines has a more expressed character during PDN than during EAE. The application of sympathoparalytics Chlorpromazine and reserpine noticeably blocks the accumulation of mediators in the nervous tissue in guinea pigs inoculated with sublethal doses of diphterial toxin or immunized with an encephalitogenic mixture, depresses the plasmocytic reaction and the production of antibodies, inhibits the development of paralysis, and protects part of the animals from fatal illness. Author

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE