Accession Number:

AD0779659

Title:

The Penetration of Antibiotics into the Cells of Mammals,

Descriptive Note:

Corporate Author:

FOREIGN TECHNOLOGY DIV WRIGHT-PATTERSON AFB OHIO

Personal Author(s):

Report Date:

1974-04-16

Pagination or Media Count:

7.0

Abstract:

The report presents data on the penetration of a number of antibiotics into mouse macrophages cultivated in vitro, with determination of antibiotic concentration in the cells. The results show that penicillin and streptomycin penetrate macrophages weakly and that their concentration in the cells is approximately half the ambient concentration, even with prolonged contact. Tetracycline and morphocycline not only penetrate the cells rapidly but apparently accumulate in the cells, since their intracellular contentrations exceeded the extracellular concentration by several times at the end of the experiment. In the first hours monomycin penetrates the cells more slowly than the tetracyclines, but it is then accumulated with great rigidity.

Subject Categories:

  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE