Accession Number:

AD0779656

Title:

Determination of Component Ratios in Industrial Preparations of Neomycin by the Chromatographic Method,

Descriptive Note:

Corporate Author:

FOREIGN TECHNOLOGY DIV WRIGHT-PATTERSON AFB OHIO

Personal Author(s):

Report Date:

1974-04-16

Pagination or Media Count:

4.0

Abstract:

The antibiotic neomycin consists of two isomeric components, B and C. It has been shown that the neomycinic antibiotics colimycin colistin, mycerin, and framycin also consist of no less than two antibiotically active components. The authors used a developed method of chromatographic comparison of N-acetyl derivatives of neomycins B and C. Production series antibiotics in the form of sulfuric acid salts were the initial materials the latter were converted into a base on resin JRA-400 in OH form, after which acetylation with acetic anhydride in absolute methanol gave N-acetyl derivatives with a yield of 93-96.

Subject Categories:

  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE