Accession Number:

AD0779540

Title:

Aldehyde Treatment of Cyanide Poisoning in Mice

Descriptive Note:

Technical rept. Sep-Oct 1973

Corporate Author:

EDGEWOOD ARSENAL ABERDEEN PROVING GROUND MD

Report Date:

1974-04-01

Pagination or Media Count:

11.0

Abstract:

Eight aldehydes have been tested as therapeutic compounds for cyanide poisoning in mice. The most effective are glyoxal trimer and glyceraldehyde. These increase the LD50 2.5 to 3 times. No correlation was found between activation of the carbonyl group resulting from nearby electron-withdrawing substituents and therapeutic value.

Subject Categories:

  • Toxicology
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE