Lymphocytes and Yellow Fever. II. Mechanisms Involved in the Transient Virus Refractory State Following Vaccination in Man with the 17-D Strain of Yellow Fever Virus.
Final comprehensive rept. 1 Aug 70-31 Dec 71,
JEFFERSON MEDICAL COLL PHILADELPHIA PA DEPT OF MICROBIOLOGY
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Human lymphocytes stimulated with PHA are capable of supporting the replication of many viruses, including 17-D, in vitro. Lymphocytes removed from 17-D virus vaccinated human volunteers, 7-11 days following immunization, failed to support 17-D virus replication in vitro by day 25, lymphocytes from most vaccines had regained completely their capacity to replicate 17-D virus. The results of our studies suggest that the 17-D virus refractory state may be attributable to the release of cytotoxic substances by certain lymphocytes in culture which in turn affect the ability of other cells to support virus replication. The substantiation of these results would suggest a similar mechanism for the control of viral infections by lymphocytes in vivo. Author
- Medicine and Medical Research