The Influence of Streptococcus Allergen and Streptolysin O on the Formation of Antitetanus Immunity
FOREIGN TECHNOLOGY DIV WRIGHT-PATTERSONAFB OH
Pagination or Media Count:
Recent works of Soviet and foreign investigators confirm the important role of products of the vital activity of streptococcus in the development of the infectious process and immunity. Experimental studies on the influence of streptococcus allergen and streptolysin O, and on the combined effect of these two preparations on the immune antitetanus reorganization of the body were conducted. Tetanus intoxication in test animals proceeded more severely and basically terminated in a lethal outcome. Thus out of 11 guinea pigs which received streptococcus allergen and were immunized with tetanus toxoid, eight died with the presence of the typical symptoms of tetanus intoxication, and three were found in a state of tetanus intoxication degree I. Of the 13 pigs which received streptolysin O nine died, the remainder were found in a state of tetanus intoxication of degrees I, II, and III. Of the nine animals which received streptococcus allergen and streptolysin O, eight died and one pig was found in a state of tetanus intoxication degree I. Thus the inhibiting influence of streptococcus allergen and streptolysin O on the formation of immunity to the toxin of tetanus is confirmed by the more severe clinical course of tetanus intoxication and the greater mortality among test animals in comparison with control.
- Medicine and Medical Research