Experimental Alteration of Graft-Versus-Host Disease in Tissue Transplantation.
Final progress rept. 1 Sep 70-31 Aug 73,
CALIFORNIA UNIV SANTA CRUZ DIV OF NATURAL SCIENCES
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The work accomplished falls into the following seven categories Development of a graft-versus-host GVH reaction to discriminate between closely-matched allogeneic cells discovery that thymocyte immunocompetence is reduced soon after immunization to alloantigens determination of the mechanism of action of soluble histocompatibility antigen in reducing immunocompetence development of a local assay to measure GVH responsiveness, in which donor cells need not migrate at all to produce their effect studies of the mechanism by which cyclophosphamide given to the host enhances the GVH reactivity of donor cells studies of the effect of antilymphocyte serum in dissociating local from systemic GVH responsiveness and studies of amoebae to determine if their surfaces possessed specific receptors analagous or homologous to cell-bound antibodies.
- Medicine and Medical Research